某些含芳碲基或烷碲基的1, 4-苯醌和1, 4-萘醌衍生物

四氯-1,4-苯醌(1)和2,3-二氯-1,4-萘醌(2)中的氯相当活泼,能和许多亲核试剂反应,如醇和酚;硫醇和硫酚;胺及许多含NH的杂环化合物。1和2与磷亲核试剂的反应也是已知的,本文报道1及2和芳碲基或烷碲基亲试剂的反应。     

Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.     

Reaction of Naphtho- and Benzimidazolequinones with Enamines. Synthesis of Condensed Benzofurans and Indoles

The reaction of naphthoquinone with nitroenamines and the interaction of benzimidazolequinones with derivatives of -aminocrotonic ester have been studied. It was shown that in the first case only the synthesis of naphthofurans occurs but in the second imidazoindoles are formed.     

Iridium catalyzed alkylation of 2′-hydroxyacetophenone with alcohols under thermal or microwave conditions

2′-Hydroxyacetophenone was alkylated with a range of substituted benzyl and heteroaryl alcohols to afford the corresponding C-alkylated products in good yields under microwave irradiation. The C-alkylated products were reacted with bromoacetonitrile to afford 2-amino-3-benzyl 1,4-naphthoquinone derivatives in moderate yields.     

Synthesis,Crystal Structure of Ruthenium 1,2-Naphthoquinone-1-oxime Complex and Its Mediated C—C Coupling Reactions of Terminal Alkynes

IntroductionRecently ,wehavereportedthecoordinationchem istryof 1,2 naphthoquinone mono oxime (nqoH)towardsplatinumgroupmetalsincludingrutheniumandrhodi um .1 8ThereactionsofnqoHwithrutheniumcarbonyl[Ru3(CO) 12 ]leadtofiveisomersofmononuclearrutheni umcarbonylcomplexesof 1,2 naphthoquinone mono oxime .1 3Thepresenceoftheliablecarbonylligandsofferstheopportunitytointroduceavarietyofligandswithspe cificfunctionalgroupsintothemolecule .3Bythisstrategy ,metal containingpolymers ,supramolecular…     

紫草试管培养诱导萘醌色素

紫草(Lithospermum erythrorhizon)离体培养诱导萘醌色素产生。添加激素I和暗培养有利于愈伤组织形成色素,诱导率达30%。培养基中增加铜和硫也能促进色素的生成,诱导率为25%。足够的无机营养和接种前蘸激素I有利于在根状体中累积色素,诱导率达70%。     

Montmorillonite K-10 catalyzed Mannich reaction: Synthesis of aminonaphthoquinone derivatives from Lawsone

An efficient one-pot protocol for the synthesis of 2-((substituted amino)(4-phenyl)methyl)-3-hydroxy-naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxy-naphthalene-1,4-dione, aromatic aldehydes and anilines/heterocyclic amines using montmorillonite K-10 as a catalyst. The advantages of this method include short reaction time, excellent yield and easy work-up.     

有机金属钼催化下的甲基萘氧化反应

本文研究了在液相条件下用有机金属钼作均相催化剂,叔丁基过氧化氢作氧化剂,把甲基萘氧化成甲基萘醌的反应。讨论了溶剂、催化剂、反应温度、氧化剂与甲基萘的配比以及萘环上不同取代基对反应的影响,     

Tagging of Model Amphetamines with Sodium 1,2‐Naphthoquinone‐4‐sulfonate: Application to the Indirect Electrochemical Detection of Amphetamines in Oral (Saliva) Fluid

Proof‐of‐concept is shown for the indirect electrochemical detection of model amphetamines, D ‐amphetamine sulfate and pseudoephedrine, based on the labeling of the amphetamine models with sodium 1,2‐naphthoquinone‐4‐sulfonate (NQS). The presence of the amphetamine models is monitored via either the reduction in the magnitude of the voltammetric peak corresponding to the electrochemical reduction of the quinone functionality of the sodium 1,2‐naphthoquinone‐4‐sulfonate or via growth of a new voltammetric peak related to reaction between the amphetamine model and NQS, both of which are well resolved from one another. The protocol is shown to be successful in artificial saliva and authentic human oral (saliva) fluid. Such a protocol may be particularly attractive for roadside testing of amphetamines in drug drivers.     

Synthesis, Crystal Structure of Ruthenium 1,2－Naphthoquinone－1－oxime Complex and Its Mediated C－－C Coupling Reactions of Ter－minal Alkynes

Substituted decarbonylation reaction of ruthenium 1,2‐naphthoquinone‐1‐oxime (1‐nqo) complex, cis‐, cis‐[Ru| ζ²‐N(O)C₁₀‐H₆O|₂(CO)₂] (1), with acetonitrile gave cis‐, cis‐[Ru | ζ²‐ N(O)C₁₀H₆O|₂(CO)(NCMe)] (2). Complex 2 was fully characterized by ¹H NMR, FAB MS, IR spectra and single crystal X‐ray analysis. Complex 2 maintains the coordination structure of 1 with the two naphthoquinonic oxygen atoms, as well as the two oximato nitrogen atoms located cis to each other, showing that there is no ligand rearrangement of the 1‐nqo ligands during the substitution reaction. The carbonyl group originally trans to the naphthoquinonic oxygen in one 1‐nqo ligand is left in its original position [O(5)‐Ru‐C(1), 174.0(6)°], while the other one originally trans to the oximato group of the other 1‐nqo ligand is substituted by NCMe [N(1)‐Ru‐N(3), 170.6(6)°]. This shows that the carbonyl trans to oximato group is more labile than the one trans to naphthoquinonic O atom towards substitution. This is probably due to the comparatively stronger ± back bonding from ruthenium metal to the carbonyl group trans to naphthoquinonic O atom, than the one trans to oximato group, resulting in the comparatively weaker Ru–‐CO bond for the latter and consequently easier replacement of this carbonyl. Selected coupling of phenylacetylene mediated by 2 gave a single trans‐dimerization product 3, while 2 mediated coupling reaction of methyl propiolate produced three products: one trans‐dimerization product 4 and two cyclotrimeric products 5 and 6.